PROBLEM TO BE SOLVED: To provide a single layer coated nanoparticle composite comprising: a core containing a biodegradable polymer and a pharmaceutical agent； and a lipid monolayer covering the core.SOLUTION: According to the present invention, there is provided a composite for neuroprotection by intranasal administration. Here, the composite comprises: a monolayer-coated nanoparticle, a pharmaceutical agent, and a targeting molecule. The lipid monolayer-coated nanoparticle comprises a core including a biodegradable polymer and a lipid monolayer coating the core. The pharmaceutical agent is present in the core including the biodegradable polymer. Furthermore, the targeting molecule is bound to the surface of the lipid monolayer-coated nanoparticle.SELECTED DRAWING: None【課題】生分解性ポリマー及び薬剤を含むコア、及び当該コアを被覆する脂質単分子層を含む、単層被覆型ナノ粒子複合体の提供。【解決手段】経鼻投与による神経保護のための複合体であって、単層被覆型ナノ粒子、薬剤、およびターゲッティング分子を含み、ここで、当該脂質単層被覆型ナノ粒子は、生分解性ポリマーを含むコア及び当該コアをコートする脂質単分子層を含み、当該薬剤は、生分解性ポリマーを含むコア中に存在し、そして当該ターゲッティング分子は、当該脂質単層被覆型ナノ粒子の表面に結合している、前記複合体。【選択図】なし
