Sung Wuk Kim,Seung Kook Park,Yeon Jung Song,Eun Sun Kim,Hyea Kyung Ahn,Jae Kap Jeong,Hung Keun Lee
申请号：
US14404001
公开号：
US09580490B2
申请日:
2013.02.07
申请国别(地区):
US
年份:
2017
代理人:
摘要：
The present invention relates to new uses of modified human tumor necrosis factor receptor-1 (TNFRI) polypeptide, and more particularly, to uses thereof for prevention and treatment of dry eye syndrome. The modified TNFRI or modified TNFRI fragment of the present invention has excellent TNFα neutralizing activity, and inhibits TNFα activity on the ocular surface of the patient to suppress inflammation induction effects related to dry eye. Therefore, the modified TNFRI or modified TNFRI fragment of the present invention exhibits remarkable effects in the prevention and treatment of dry eye syndrome, and thus can be very useful in the prevention and treatment of dry eye syndrome.
