A wire guide grabbing mechanism includes an elongate mandrel having a proximal and distal mandrel end, and a grabber irreversibly attached to the mandrel. The grabber includes a plurality of struts arranged in a reticulated pattern and a plurality of openings defined by the plurality of struts. The grabber is adjustable between an expanded configuration at which the plurality of struts are spread out relative to one another and a contracted configuration at which the plurality of struts are condensed, such that a wire guide may be enmeshed by the grabber in the contracted configuration. Related methodology is also disclosed.