A sexual stimulating system with feedback control includes a physiological sensor, a sexual stimulator, and a processing module. The physiological sensor measures a physiological response of a user under sexual stimulation, and generates a sensor signal according to a result of the measurement of the physiological response. The sexual stimulator applies the sexual stimulation. The processing module is electrically connected to the physiological sensor and the sexual stimulator, receives the sensor signal, performs an analytical procedure upon the sensor signal for generating digital data, and generates a driving signal according to the digital data to control a degree of the sexual stimulation.