An exemplary system, method and computer-accessible medium for detecting deposits in subjects can be provided, which can include, for example receiving information related to reference information obtained from measurements in further subjects, obtaining a threshold regarding a suspect data points in the information, and detecting the deposits in the subjects based on the threshold of the suspect data points. Retardances induced by the deposits can be located below the deposits using references that can be positioned above the deposits. Inner and outer segments of a photoreceptor layer can be used as a reference to collect the retardances located below a retinal pigment epithelium—；Bruch's membrane complex.
