The present disclosure provides methods for treating cancer. Methods for treating cancer can include administration of pentostatin and cyclophosphamide followed by administration of manufactured T cells. The present disclosure further provides for methods for producing such manufactured T cells, said manufactured T cells and compositions comprising said manufactured T cells.La présente invention concerne des méthodes de traitement d'un cancer. Les méthodes de traitement d'un cancer peuvent comprendre l'administration de pentostatine et de cyclophosphamide, suivie par l'administration de lymphocytes T fabriqués. L'invention concerne également des procédés de production de ces lymphocytes T fabriqués, lesdits lymphocytes T fabriqués et des compositions comprenant lesdits lymphocytes T fabriqués.