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Diazepinona derivatives and Methods for treating infections of hepatitis B
专利权人:
NOVIRA THERAPEUTICS; INC.
发明人:
申请号:
ARP170101814
公开号:
AR108925A1
申请日:
2017.06.30
申请国别(地区):
AR
年份:
2018
代理人:
摘要:
In the present description provides compounds useful for the treatment of HBV infection in a subject in need of such Pharmaceutical compositions, and Methods for inhibiting,Suppress or prevent the HBV infection in the subject.Claim 1: a compound of formula (1) or a pharmaceutically acceptable Salt of this, where is ch₂ or C = o r¹ c₁₋₆ is H, alkyl, alkyl alquenilo c₁₋₆, c₁₋₆ - Oh or haloalquilo R², c₁₋₆In each case, Select regardless of Oh, Halo, c₁₋₆ alquileno c₁₋₆ alkyl, alkyl, cycloalkyl c₃₋₆ c₀₋₆ c₀₋₆ -, alkyl - heterocicloalquilo c₂₋₆ c₀₋₆ or⁶ alkyl, alkyl -, - N (c₀₋₆ ₂, r⁷)C₀₋₆ - sr⁸ alkyl, alkyl c₀₋₆ - S (o) r⁸, alkyl c₀₋₆ - S (o) ₂r⁸ c₀₋₆ alkyl, - C (o) or⁹, OC (c₀₋₆ - alkyl or alkyl c₀₋₆) r⁹, OC (OC) or⁹, c₀₋₆ alkyl - (o) n (r⁷ ₂ and rent) c₀₋₆ - C (o) n (₂, r⁷)Where the alquileno alkyl, cycloalkyl, optionally substituted and heterocicloalquilo are with 1, 2 or 3 groups,Each selected regardless of Oh and Halo or two groups together form a R² Spiro c₃₋₆ cycloalkyl, optionally substituted cycloalkyl is where groups with 1, 2 or 3,Each selected individually - and Halo r³ in each case is selected independently of - Oh, c₁₋₆ alkyl, Halo, haloalquilo c₁₋₆,- c₁₋₆ alkyl and o-alkyl c₁₋₆ - Oh r⁴ is selected (crᵃrᵇ ₚ - (heteroaryl) c₁₋₉, crᵃrᵇ ₚ (aryl) - c₆₋₁₂, crᵃrᵇ ₚ cycloalkyl c₃₋₇) - and (- heterocicloalquilo c₂₋₆ ₚ crᵃrᵇ), in which the aryl, heteroaryl,Heterocicloalquilo are optionally substituted cycloalkyl and 1, 2, 3 or 4 groups, each independently selected from - Oh, Halo, - CN, - sf₅, alkyl c₁₋₆, haloalquilo c₁₋₆,- c₁₋₆ alkyl and o-alkyl c₁₋₆ - Oh r⁵ is selected from h, alkyl and alkyl c₁₋₆ c₁₋₆ - Oh r⁶ is selected from h, alkyl c₁₋₆, haloalquilo c₁₋₆, alquenilo c₁₋₆ alkyl and cycloalkyl c₃₋₆ r⁷, c₀₋₆ -In each case, Select c₁₋₆ regardless of H, alkyl, haloalquilo c₁₋₆,C₍o₎₋ₐₗqᵘⁱₗₒ c₁₋₆ and alkyl c₁₋₆ - Oh r⁸ is selected from H and alkyl c₁₋₆ r⁹ is selected from H and alkyl c₁₋₆ rᵃ in each case is selected regardless of H, Oh, c₁₋₆ alkyl, haloHaloalquilo c₁
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