Inhibitors of glutaminyl cyclase

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专利权人:

Ulrich Heiser;Hans-Ulrich Demuth;Torsten Hoffmann;Daniel Ramsbeck;Livia Boehme

发明人:

Ulrich Heiser,Daniel Ramsbeck,Torsten Hoffmann,Livia Boehme,Hans-Ulrich Demuth

申请号：

US13040159

公开号：

US09181233B2

申请日:

2011.03.03

申请国别(地区):

US

年份:

2015

代理人:

摘要：

The invention relates to novel heterocyclic derivatives as inhibitors of glutaminyl cyclase (QC, EC 2.3.2.5). QC catalyzes the intramolecular cyclization of N-terminal glutamine residues into pyroglutamic acid (5-oxo-prolyl, pGlu*) under liberation of ammonia and the intramolecular cyclization of N-terminal glutamate residues into pyroglutamic acid under liberation of water.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/