HETEROCYCLIC INHIBITORS OF GLUTAMINYL CYCLASE (QC, EC 2.3.2.5)

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专利权人:

PROBIODRUG AG

发明人:

HEISER, ULRICH,GAERTNER, ULF-TORSTEN,DEMUTH, HANS-ULRICH

申请号：

SG2012058806

公开号：

SG183229A1

申请日:

2011.03.10

申请国别(地区):

SG

年份:

2012

代理人:

摘要：

The invention relates to novel heterocyclic derivatives as inhibitors of glutaminyl cyclase (QC, EC 2.3.2.5). QC catalyzes the intramolecular cyclization of N-terminal glutamine residues into pyroglutamic acid (5-oxo-prolyl, pGlu*) under liberation of ammonia and the intramolecular cyclization of N-terminal glutamate residues into pyroglutamic acid under liberation of water.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/