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NEW ARYLATED CAMPHENES, METHODS FOR PRODUCING AND USING THEM
专利权人:
LTD.;JISSUM RISERCH DIVELOPMENT KOMPANI OF DZE KHEBRJUJUNIVERSITI OF IERUSALIM
发明人:
MECHULAM Rafael (IL),МЕЧУЛАМ Рафаель (IL),MAGID Lital (IL),МАГИД Литаль (IL),SHOKHAMI Ester (IL),ШОХАМИ Эстер (IL),BAB Itai (IL),БАБ Итаи (IL),MECHULAM RAFAEL,МЕЧУЛАМ Рафаель,MAGID LITAL,МАГИД Литаль,SHOKHAMI ESTER,ШОХАМИ Эстер,BAB ITAI,БАБ Итаи
申请号:
RU2012106897/04
公开号:
RU0002578715C2
申请日:
2010.11.18
申请国别(地区):
RU
年份:
2016
代理人:
摘要:
FIELD: medicine, pharmaceutics.SUBSTANCE: invention refers to compounds specified in the following list: methyl-2-(2,6-dimethoxy-4-(2-methyloctan-2-yl)phenyl)-7,7-dimethylbicyclo[2.2.1]hept-2-en-1-carboxylate; methyl-2-(2,6-dimethoxy-4-pentylphenyl)-7,7-dimethylbicyclo[2.2.1]hept-2-en-1-carboxylate; 2-(2,6-dimethoxy-4-(2-methyloctan-2-yl)phenyl)-1,7,7-trimethylbicyclo[2.2.1]hept-2-ene; (2-(2,6-dimethoxy-4-(2-methyloctan-2-yl)phenyl)-7,7-dimethylbicyclo[2.2.1]hept-2-en-1-yl)methanol; (2-(2,6-dimethoxy-4-pentylphenyl)-7,7-dimethylbicyclo[2.2.1]hept-2-en-1-yl)methanol; 2-(2,6-dimethoxy-4-(2-methyloctan-2-yl)phenyl)-7,7-dimethylbicyclo[2.2.1]hept-2-en-1-carboxylic acid; 2-(2,6-dimethoxy-4-pentylphenyl)-7,7-dimethylbicyclo[2.2.1]hept-2-en-1-carboxylic acid; 3-(2,6-dimethoxy-4-(2-methyloctan-2-yl)phenyl)-1,7,7-trimethylbicyclo[2.2.1]hept-2-ene; 3-(2,6-dimethoxy-4-pentylphenyl)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-one; 3-(2,6-dimethoxy-4-(2-methyloctan-2-yl)phenyl)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-one; 3-(2,6-dimethoxy-4-pentylphenyl)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-ol; and 3-(2,6-dimethoxy-4-(2-methyloctan-2-yl)phenyl)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-ol, which are bound to CB2 receptor stimulation and which are under the good influence of CB2 receptor stimulation.EFFECT: compounds are applicable for treating a condition specified in inflammation, pain, neurological or neurodegenerative disorders, hepatic diseases, cerebral injuries, atherosclerosis, disorders related to anti-fibrinogen action, inflammatory intestinal disease and nausea or any combination thereof.5 cl, 2 tbl, 8 dwg, 3 exИзобретение относится к соединениям, выбранным из следующего списка: метил-2-(2,6-диметокси-4-(2-метилоктан-2-ил)фенил)-7,7-диметилбицикло[2.2.1]гепт-2-ен-1-арбоксилат; метил-2-(2,6-диметокси-4-пентилфенил)-7,7-диметилбицикло[2.2.1]гепт-2-ен-1-карбоксилат; 2-(2,6-диметокси-4-(2-метилоктан-2-ил)фенил)-1,7,7-триметилбицикло[2.2.1]гепт-2-ен; (2-(2,6-диметокси-4-(2-метилокта
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