A compound of Formula (I) or a pharmaceutically acceptable salt thereof, or hydrate thereof, ** Formula ** (wherein, X1 represents CH2 or O, k represents 1, 2 or 3, R3 represents H or C1 alkyl -6, X2 represents CH or N, L1 represents C1-6 alkylene, R1 represents H or C1-6 alkyl, X3 represents CH or N, L2 represents C1-6 alkylene, R5 represents H or C1-6 alkyl, R6 represents H , C1-6 alkyl, C1-6 alkyl substituted with one to two of -OR0, -C (O) -C1-6 alkyl, -S (O) m-C1-6 alkyl, -C1-6-N alkylene ( C1-6 alkyl) 2, -R00-heterocycle, -R00-phenyl or -R00-C3-10 cycloalkyl, wherein the C3-10 heterocycle, phenyl and cycloalkyl may be substituted with one to two C1-6 alkyl or C (O) -C1-6 alkyl, and -R00 may be substituted with a -OR0, R00 represents a bond or C1-6 alkylene, R0 represents H or C1-6 alkyl, m represents 0, 1 or 2, L3 represents C1-6 alkylene, n represents 0 or 1, R4 represents H, C1-6 alkyl, -C 1-6 alkylene-COO-R0, -C 1-6 alkylene-OR0, -C 1-6 alkylene-NHR0, -C1-6- N alkylene (C1-6 alkyl) 2 or C3-10 cycloalkyl, L4 represents a bond, O or -NR0-, and represents -R00-monocyclic heterocycle-R00-, -R00-phenyl-R00-, C1-6-NR0-C1-6 alkylene-, C1-6 alkylene-C1-6 alkylene or C1-6 alkylene which may be substituted with a hydroxyl group, and R2 represents H or C1-6 alkyl)； wherein the heterocycle is a 3- to 15-membered mono to tricyclic heterocycle containing 1 to 4 heteroatoms selected from O, S and N.Un compuesto de Fórmula (I) o una sal farmacéuticamente aceptable del mismo, o hidrato del mismo,**Fórmula** (en la que, X1 representa CH2 u O, k representa 1, 2 ó 3, R3 representa H o alquilo C1-6, X2 representa CH o N, L1 representa alquileno C1-6, R1 representa H o alquilo C1-6, X3 representa CH o N, L2 representa alquileno C1-6, R5 representa H o alquilo C1-6, R6 representa H, alquilo C1-6, alquilo C1-6 sustituido con uno a dos de -OR0, -C(O)-alquilo C1-6, -S(O)m-alquilo C1-6, -alquileno C1-6-N(alquil C1-6)2, -R00-heterociclo, -R00-fenilo o -R00-cicloalquilo C3-10, en la qu
