The present invention relates, in one aspect, to an adduct of formula O-PF-A, in which O is an oil PF is a perfluoropolyether phosphate (PFPE phosphate) A is at least one substance selected from: (X) a water-soluble polyhydroxylated substance and (Y) a water-insoluble inorganic substance and to topical applications thereof in particular in the cosmetic and pharmaceutical field.