Humanized anti Epiregulin Antibody； vector； host Cell； production method； Pharmaceutical composition that comprises a Therapeutic Agent against cancer； and he understands.

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专利权人:

CHUGAI SEIYAKU KABUSHIKI KAISHA

发明人:

SHIRAIWA, HIROTAKE,ESAKI, KEIKO.,IGAWA, TOMOYUKI,KURAMOCHI, TAICHI,MAEDA, ASTUHIKO,TAMBA SHIGERO,TSUNODA HIROYUKI,TACHIBANA TATSUHIKO,KONOSHITA YASUKO,SUZUKI MASAMI,KATO ATSUHIKO,TAKEIRI ETSUKO,HASHIM

申请号：

CL2014001730

公开号：

CL2014001730A1

申请日:

2014.06.26

申请国别(地区):

CL

年份:

2014

代理人:

摘要：

The inventors successfully produced anti-Epiregulin antibodies showing cross-species reactivity between cynomolgus monkey (non-human animals) and human, anti-Epiregulin antibodies with suppressed chemical degradation, anti-Epiregulin antibodies with lowered isoelectric point, anti-Epiregulin antibodies with increased thermal denaturation midpoint temperature, and anti-Epiregulin antibodies with reduced amount of aggregate by performing appropriate amino acid residue substitutions in the variable-region sequences of the humanized EP27 antibody which inhibits growth of cancer cells by exhibiting cytotoxic activity and neutralizing activity against anti-human Epiregulin-expressing cancer cells.ANTICUERPO ANTI-EPIRREGULINA HUMANIZADO； VECTOR； CELULA HUESPED； METODO DE PRODUCCION； COMPOSICION FARMACEUTICA QUE LO COMPRENDE； Y AGENTE TERAPEUTICO CONTRA EL CANCER QUE LO COMPRENDE.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/