An antibody binding to TWEAK, characterized by binding to TWEAK characterized by comprising as heavy chain variable domain a CDR3H selected from the group consisting of SEQ ID NO: 8, 16 or 24.ANTICUERPO ANTI-PROTEINA TWEAK HUMANA; ACIDO NUCLEICO QUE LO CODIFICA; VECTOR; CELULA HUESPED; METODO DE PRODUCCION; COMPOSICION FARMACEUTICA QUE LO COMPRENDE.