Lieven Meerpoel,Louis Jules Roger Marie Maes,Kelly de Wit,Koen Jan Ludovicus Augustyns
申请号：
US15342646
公开号：
US09975899B2
申请日:
2016.11.03
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The present invention is concerned with novel antifungal 5,6-dihydro-4H-pyrrolo-[1,2-a][1,4]benzodiazepines and 6H-pyrrolo[1,2-a][1,4]benzodiazepines substituted with heterocyclic derivatives of Formula (I)wherein R1, R2, R3, R4 and Het have the meaning defined in the claims. The compounds according to the present invention are active mainly against dermatophytes and systemic fungal infections. The invention further relates to processes for preparing such novel compounds, pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.
