KONTTURI, Kyösti;HIRVONEN, Jouni;POHJAKALLIO, Maija;VIITALA, Lauri;NOVAGENT OY
发明人:
KONTTURI, Kyösti,HIRVONEN, Jouni,VIITALA, Lauri,POHJAKALLIO, Maija
申请号：
FIFI2013/050782
公开号：
WO2014/027136A1
申请日:
2013.07.31
申请国别(地区):
FI
年份:
2014
代理人:
摘要：
A device based on iontophoresis and intended for transdemal dosing of an active agent, said device comprising - a pair of electrodes (11,12), which can be connected to a direct-current source, and - two chambers (13, 14), separated from each other, the first chamber (13) containing the active agent, each chamber having a porous membrane (15, 16) on the side facing the individual's skin, and - the first chamber (13) being divided in two sections (13a, 13b) in such a manner that the first chamber section ( 13 a) is in contact with the electrode (11) and the second chamber section (13b) is in contact with the membrane (15) coming into contact with an individul's skin, wherein between the chamber sections (13a and 13b) is a membrane (18) selectively permeable either to cations or to anions, - the first chamber section (13a) containing an electrolyte and the second chamber section (13b) containing the ionic active agent, bound to a ion exhanger therein, which in turn preferably comprises fibres and ion exchanging groups bound thereto. The invention is characterized in that - the electrodes (11,12) comprise a porous carbon fibre textile (30) which is mixed with a hydrophobic agent or onto which is fitted a hydrophobic porous, preferably micro-porous membrane (31), and - into the chamber section (13a) comprising the analyte is added a fibre grafted with buffering ion exchanging groups.L'invention porte sur un dispositif basé sur l'iontophorèse et destiné à l'administration transdermique de doses d'un principe actif, ledit dispositif comprenant une paire d'électrodes (11, 12), qui peuvent être connectées à une source de courant continu, et deux chambres (13, 14), séparées l'une de l'autre, la première chambre (13) contenant le principe actif, chaque chambre ayant une membrane poreuse (15, 16) sur le côté en regard de la peau de l'individu et la première chambre (13) étant divisée en deux sections (13a, 13b) d'une manière telle que la première section de chambre (13a) soit e
