Chen, Jinsheng,Illig, Carl R.,Wall, Mark,Meegalla, Sanath K.,Ballentine, Shelley K.,Wilson, Kenneth,Desjarlais, Renee Louise
申请号：
AU2007240439
公开号：
AU2007240439B2
申请日:
2007.04.18
申请国别(地区):
AU
年份:
2012
代理人:
摘要：
The invention is directed to compounds of Formula (I): wherein Z, X, J, Rand W are set forth in the specification, as well as solvates, hydrates, tautomersand pharmaceutically acceptable salts thereof, that inhibit protein tyrosinekinases, especially c-fms kinase. Methods of treating autoimmune diseases；and diseases with an inflammatory component； treating metastasis from ovariancancer, uterine cancer, breast cancer, colon cancer, stomach cancer, hairycell leukemia and non-small lung carcinoma； and treating pain, including skeletalpain caused by tumor metastasis or osteoarthritis, or visceral, inflammatory,and neurogenic pain； as well as osteoporosis, Paget's disease, and otherdiseases in which bone resorption mediates morbidity including arthritis,prosthesis failure, osteolytic sarcoma, myeloma, and tumor metastasis to bonewith the compounds of Formula (I), are also provided.
