CARL R. ILLIG,SHELLEY K. BALLENTINE,JINSHENG CHEN,SANATH MEEGALLA,M. JONATHAN RUDOLPH,MARK J. WALL,KEN WILSON,RENEE DESJARLAIS,CARL MANTHEY,CHRISTOPHER MOLLOY,CHRISTOPHER FLORES
申请号：
PT05815361
公开号：
PT1807077T
申请日:
2005.10.20
申请国别(地区):
PT
年份:
2017
代理人:
摘要：
The invention is directed to compounds of Formula (I): wherein A, X, R2 and W are set forth in the specification, as well as solvates, hydrates, tautomers and pharmaceutically acceptable salts thereof, that inhibit protein tyrosine kinases, especially c-fms kinase. Methods of treating autoimmune diseases and diseases with an inflammatory component treating metastasis from ovarian cancer, uterine cancer, breast cancer, colon cancer, stomach cancer, hairy cell leukemia and non-small lung carcinoma and treating pain, including skeletal pain caused by tumor metastasis or osteoarthritis, or visceral, inflammatory, and neurogenic pain as well as osteoporosis, Pagets disease, and other diseases in which bone resorption mediates morbidity including arthritis, prosthesis failure, osteolytic sarcoma, myeloma, and tumor metastasis to bone with the compounds of Formula (I), are also provided.
