The present invention relates a preparation method of a pharmaceutical composition comprising quinoline derivatives or salt thereof. In particular, the present invention relates a preparation method of a pharmaceutical composition comprising (R,E)-N-(4-(3-chloro-4-(pyridyl-2-methoxy) phenylamino)-3-cyano-7-ethoxyquinolin-6-yl)-3-(1-methylpyr rolidin-2-yl)-acrylamide or its pharmacologically acceptable salts, including during the preparation process of the present composition, using wetting agent which comprises at least one of the organic solvent to conduct wet granulation. The composition has the characteristics of rapid dissolution. The pharmaceutical composition prepared by the method of the invention has the characteristics of uniform particle distribution in the preparation process, rapid and uniform dissolution of the composition.本發明提供了一種含有喹啉衍生物或其鹽的醫藥組成物的製備方法。具體而言，本發明提供了一種含有(R,E)-N-(4-(3-氯-4-(吡啶-2-基甲氧基)苯基胺基)-3-氰基-7-乙氧基喹啉-6-基)-3-(1-甲基吡咯烷基-2-基)-丙烯醯胺或其藥理學上可接受的鹽的醫藥組成物的製備方法，包括在本發明所述的醫藥組成物的製備過程中，使用含有至少一種有機溶劑的潤濕劑進行濕法製粒。採用本發明所述方法製備的醫藥組成物具有製備過程中的顆粒分佈均勻，組成物溶出迅速而且均一的特點。
