A mattress structure including a base, an air bag structure and a fluid driving device is provided. The air bag structure is disposed on the base. The air bag structure includes a plurality of independent sub air bag structures. A plurality of supporting structures are disposed in each of the sub air bag structures. The fluid driving device is connected to the sub air bag structures so as so inject fluid to the sub air bag structures selectively. When the fluid driving device injects the fluid to at least one of the sub air bag structures so as to make the at least one of the sub air bag structures expand, each of the supporting structure is connected to two opposite surfaces of the expanded sub air bag structure.