YOUNG SHIN CHO,MICHAEL DAVID SHULTZ,QIAN ZHAO,ZHUOLIANG CHEN,THOMAS RAYMOND CAFERRO,JAMES SUTTON,YAPING WANG,ABRAN Q. COSTALES,JULIAN ROY LEVELL,GANG LIU,JAMES R. MANNING,MARTIN SENDZIK,CYNTHIA SHAFER
申请号：
ARP140101012
公开号：
AR095311A1
申请日:
2014.03.14
申请国别(地区):
AR
年份:
2015
代理人:
摘要：
Compound of the formula (1) in the treatment of diseases or disorders associated with such mutant HDI proteins including but not limited to, cell proliferation disorders such as cancer. Claim 1: A compound according to formula (1) wherein R¹ is hydrogen, methyl or ethyl； R²ᵃ is hydrogen, methyl or C₁₋₃ haloalkyl；Rs7495es Oh, halogen, alcoxyl c83215331；Halogenated tar c83218323；NH.8322；NH (ch832323) or n (ch832323) 8322；R³ and R⁴ are each independently hydrogen, methyl or ethyl or R³ and R⁴ are joined to form cyclopropyl, cyclobutyl or oxetanyl； R⁵ and R⁶ are each independently hydrogen, deuterium, halogen, -C (O) OCH₃,C₁₋₃ alkyl or C₁₋₃ haloalkyl；R⁷ is a compound of the group of formulas (2) in which: ring A is a 6-membered heteroaryl ring having one to three nitrogen atoms； Ring B is a 5-membered heteroaryl ring having one to four heteroatoms each independently selected from the group consisting of N, O and S； X is N or CH； each R⁸ is independently hydrogen, halogen, C₁₋₃ alkyl,Halogenated tar c83218323；C₁₋₃ alkoxy or Co haloalkoxy；n is 1 or 2； R⁹ is hydrogen, halogen, haloalkyl C₁₋₃,optionally substituted C₁₋₆ alkyl, optionally substituted C₁₋₆ cycloalkyl, optionally substituted aryl, optionally substituted 5 or 6 membered heterocyclic, optionally substituted heteroaryl, -OR⁹ᵃ,-SO RC (O) NHRCh8322； r8313； 7495 or ch8323； r8313； 74955；as long as X is N, R⁹ is hydrogen, haloalkyl C₁₋₃,optionally substituted C₁₋₆ alkyl, optionally substituted C₁₋₆ cycloalkyl, optionally substituted aryl, optionally substituted heteroaryl, -SO₂R⁹ᵃ or C (O) NHR⁹ᵃ,wherein: said C₁₋₆ alkyl is optionally substituted by one to three substituents independently selected from the group consisting of OH, phenyl and phenoxy, and said C₃₋₆ cycloalkyl,5- or 6-membered heterocyclic, aryl and heteroaryl are each optionally substituted by one to three substituents independently selected from the group consisting of: halogen, hydroxyl, cyano, -NRR, C₁₋₆ alkyl,C₁₋₆ haloalkyl,C₁₋₃ alkoxy,e. Halogenated
