compound, pharmaceutical composition, and methods for inhibiting the hedgehog pathway and for reducing cell proliferation, differentiation and / or affecting modulation of the stromal microenvironment
Alexander Hird,Benjamin Fauber,Bin Yang,Daniel John Russel,James Janetka,Leslie Dakin,Qibin Su,Xiaolan Zheng
申请号：
BRPI0816050
公开号：
BRPI0816050A2
申请日:
2008.08.29
申请国别(地区):
BR
年份:
2017
代理人:
摘要：
The present disclosure relates to heterocyclic amide compounds, which are useful for inhibiting the Hedgehog pathway, and their use in treating a disease or medical condition mediated alone or in part by Hedgehog pathway inhibition. Also disclosed are methods for manufacture of these compounds, pharmaceutical compositions including these compounds, and use of these compounds in the manufacture of medicaments for treating such diseases and medical conditions in a subject. Formula (IA) with the provisio that either R2 or R3 is (Z).
