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GLYPICAN-3-BINDING FIBRONECTIN BASED SCAFFOLD MOLECULES
专利权人:
BRISTOL-MYERS SQUIBB COMPANY
发明人:
Dasa LIPOVSEK,Joseph TOTH,Ginger C. RAKESTRAW,Irvith M. CARVAJAL,Stanley Richard KRYSTEK, Jr.,Steven R. O'NEIL,Guodong CHEN,Richard Y. HUANG,Bryan C. BARNHART,John Thomas LOFFREDO,Christina TERRAGNI
申请号:
US16751788
公开号:
US20200262893A1
申请日:
2020.01.24
申请国别(地区):
US
年份:
2020
代理人:
摘要:
Provided herein are polypeptides which include tenth fibronectin type III domains (10Fn3) that bind to glypican-3. Also provided are fusion molecules comprising a 10Fn3 domain that bind to glypican-3 for use in diagnostic and therapeutic applications. Glypican-3 10Fn3 drug conjugates are also provided.
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