The present invention relates to new combinations of treatments for abnormal dopamine deficiency disorders, and related conditions, comprising deuterated catecholamine derivatives and catechol-O-methyltransferase (COMT) inhibitors.本發明係關於用於治療異常多巴胺缺乏症、及相關症狀的新穎組合,包含經氘化兒茶酚胺衍生物以及兒茶酚-O-甲基轉移酶抑制劑(COMT)抑制劑。