Preparation of (R,R-)-fenoterol and (R,R)- or (R,S)-fenoterol analogues and their use in treating congestive heart failure

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专利权人:

THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES

发明人:

WAINER, Irving W.,XIAO, Rui Ping,ZHU, Weizhong,CHAKIR, Khalid,BEIGI, Farideh M.,ABERNETHY, Darrell R.

申请号：

AU2013202127

公开号：

AU2013202127A1

申请日:

2013.03.28

申请国别(地区):

AU

年份:

2013

代理人:

摘要：

#$%^&*AU2013202127A120130502.pdf#####PREPARATION OF (RR)-FENOTEROL AND (R,R)- OR (RS)FENOTEROL ANALOGUES AND THEIR USE IN TREATING CONGESTIVE HEART FAILURE ABSTRACT This disclosure concerns the discovery of (R,R)- and (RS)-fenoterol analogues which are highly effective at binding J2-adrenergic receptors. Exemplary chemical structures for these analogues are provided. Also provided are pharmaceutical compositions including the disclosed (RR)-fenoterol and fenoterol analogues, and methods of using such compounds and compositions for the treatment of cardiac disorders such as congestive heart failure and pulmonary disorders such as asthma or chronic obstructive pulmonary disease. 95

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