DESHPANDE SHRIKANT,HUANG HAICHUN,SRINIVASAN MOHAN,CARDARELLI JOSEPHINE M.,WANG CHANGYU,PASSMORE DAVID,RANGAN VANGIPURAM S.,LANE THOMAS E.,KEIRSTEAD HANS S.,LIU MICHAEL T.
申请号：
SI200431929
公开号：
SI1691837T1
申请日:
2004.12.10
申请国别(地区):
SI
年份:
2012
代理人:
摘要：
The present invention provides isolated monoclonal antibodies, particularly human antibodies, that bind to IP-10 with high affinity, inhibit the binding of IP- 10 to its receptor, inhibit IP-10-induced calcium flux and inhibit IP-10-induced cell migration. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for inhibiting IP-10 activity using the antibodies of the invention, including methods for treating various inflammatory and autoimmune diseases.
