SHRIKANT DESHPANDE,HAICHUN HUANG,MOHAN SRINIVASAN,JOSEPHINE M. CARDARELLI,CHANGYU WANG,DAVID PASSMORE,VANGIPURAM S. RANGAN,THOMAS E. LANE,HANS S. KEIRSTEAD,MICHAEL T. LIU
申请号：
PT04813771
公开号：
PT1691837E
申请日:
2004.12.10
申请国别(地区):
PT
年份:
2012
代理人:
摘要：
The present invention provides isolated monoclonal antibodies, particularly human antibodies, that bind to IP-10 with high affinity, inhibit the binding of IP- 10 to its receptor, inhibit IP-10-induced calcium flux and inhibit IP-10-induced cell migration. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for inhibiting IP-10 activity using the antibodies of the invention, including methods for treating various inflammatory and autoimmune diseases.
