PRIEKE, HENNIG,DOODS, HENRI,KUELZER, RAIMUND,PFAU, ROLAND,STENKAMP, DIRK,PELCMAN, BENJAMIN,ROENN, ROBERT
申请号：
PE0002662013
公开号：
PE11172013A1
申请日:
2011.08.19
申请国别(地区):
PE
年份:
2013
代理人:
摘要：
Referring to a benzimidazole Derivative of formula (i), wherein R1 and R2 are Halo C1 - C3 alkyl, optionally substituted with Fluorine W is C (or c), or (OR) M is c1-c6 alkyl, cycloalkyl C3 - C7, among others R8 is H, halogen, alkyl of C1 - C3, among others R6 C1 - C5 is H, alkyl, cycloalkyl C3 C5 alkyl C 0 - C2, among others R7 is Halo, or C1 - C5 alkyl, among others is C1 C8 alkyl, phenyl, indanilo,Naphthyl, among others.Preferred compounds are: amide acid (Trans - 4 - trifluoromethyl - ciclohex - 1 - il) - 2 - (2,6 - Dichloro - [3 - (2,2 Dimethyl propionilamino) methyl] - (phenylamino) - 6 - 2.2 - difluoro - ethoxy - 1 - methyl) - 1H benzimidazole - 5 - carboxylic acid amide, N - (trans-4 - trifluoromethyl - ciclohex - 1 - il) - 2 - (-) - 2,2-dimethyl propionilamino Methyl] - phenylamino) - 6 - (2,2 - difluoroetoxi) - 1H benzimidazole - 5 - carboxylic acid,Amide acid n - (trans-4 - trifluoromethyl - ciclohex - 1 - il) - 2 - (2,6 - Dichloro - dimethyl - 3 - [2 - propionilamino) methyl] - phenylamino) - 6 - fluoro - 1 - methyl - 5 - 1H benzimidazole carboxylic acid, among others. It also relates to a Pharmaceutical composition.These compounds are inhibitors of microsomal prostaglandin e2 synthase 1 (mpges-1) and are useful in the treatment of inflammatory diseases and associated conditions such as inflammatory PainREFERIDA A UN DERIVADO DE BENCIMIDAZOL DE FORMULA (I), DONDE R1 Y R2 SON HALO, ALQUILO C1-C3 OPCIONALMENTE SUSTITUIDO CON FLUOR W ES C(O), C(O)O M ES ALQUILO C1-C6, CICLOALQUILO C3-C7, ENTRE OTROS R8 ES H, HALOGENO, ALQUILO C1-C3, ENTRE OTROS R6 ES H, ALQUILO C1-C5, CICLOALQUILO C3-C5-ALQUILO C0-C2, ENTRE OTROS R7 ES HALO, O-ALQUILO C1-C5, ENTRE OTROS A ES ALQUILO C1-C8, FENILO, INDANILO, NAFTILO, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: AMIDA DEL ACIDO N(TRANS-4-TRIFLUOROMETIL-CICLOHEX-1-IL)-2-{2,6-DICLORO-3-[(2,2-DIMETIL-PROPIONILAMINO)-METIL]-FENILAMINO}-6-(2,2-DIFLUORO-ETOXI)-1-METIL-1H-BENCIMIDAZOL-5-CARBOXILICO, AMIDA DEL ACIDO N-(TRANS-4-TRIFLUOROME
