SAPREME TECHNOLOGIES B.V.;CHARITÉ - UNIVERSITÄTSMEDIZIN BERLIN
发明人:
POSTEL, Ruben,FUCHS, Hendrik
申请号：
EPEP2019/084210
公开号：
WO2020/126609A2
申请日:
2019.12.09
申请国别(地区):
EP
年份:
2020
代理人:
摘要：
The invention relates to antibody-drug conjugates (ADC) that are potentiated by co-administration of the ADC with a moiety comprising covalently linked saponin. The invention also relates to antibody- oligonucleotide conjugates (AOC) that are potentiated by co-administration of the AOC with a moiety comprising covalently linked saponin. The invention also relates to ADCs and AOCs which are conjugated with a saponin via a covalent linker. The invention further relates to an effector moiety such as a toxin or an antisense oligonucleotide such as for example a BNA, conjugated with a saponin via a covalent linkage. The invention also relates to a BNA covalently conjugated with a targeting moiety such as an antibody. The invention also relates to therapeutic combinations comprising a first pharmaceutical composition comprising a conjugate of a cell-targeting moiety such as an antibody and an antisense oligonucleotide such as a BNA covalently bound thereto, and comprising a second pharmaceutical composition comprising either a free saponin, or a conjugate of a cell-targeting moiety such as an antibody with a saponin covalently linked thereto. Furthermore, the invention relates to any of these conjugates or therapeutic compositions or therapeutic combinations, for use as a medicament. The invention also relates to any of these conjugates or therapeutic compositions or therapeutic combinations, for use in a method for the treatment or the prophylaxis of a cancer. Finally, the invention relates to methods for producing any of these conjugates of the invention.L'invention concerne des conjugués anticorps-médicament (ADC) qui sont potentialisés par co-administration de l'ADC avec une fraction comprenant de la saponine liée de manière covalente. L'invention concerne également des conjugués anticorps-oligonucléotide (AOC) qui sont potentialisés par co-administration de l'AOC avec un fraction comprenant de la saponine liée de manière covalente. L'invention concerne également des
