Antigen-binding molecules comprising an Fc region comprising a polypeptide having: (i) C at the position corresponding to position 242, and C at the position corresponding to position 334, and (ii) one or more of: A at the position corresponding to position 236, D at the position corresponding to position 239, E at the position corresponding to position 332, L at the position corresponding to position 330, K at the position corresponding to position 345, and G at the position corresponding to position 430 are disclosed. Also discloses are constituent polypeptides of such Fc regions, nucleic acids encoding such antigen-binding molecules and polypeptides, compositions comprising such antigen-binding molecules, polypeptides and nucleic acids, and methods using the same.本發明揭示包含Fc區之抗原結合分子，該Fc區包含具有以下之多肽：(i)在對應於位置242之位置的C及在對應於位置334之位置的C；以及(ii)以下中之一或多者：在對應於位置236之位置的A、在對應於位置239之位置的D、在對應於位置332之位置的E、在對應於位置330之位置的L、在對應於位置345之位置的K及在對應於位置430之位置的G。亦揭示此等Fc區之成分多肽、編碼此等抗原結合分子及多肽的核酸、包含此等抗原結合分子、多肽及核酸之組合物以及使用該等組合物之方法。
