A therapeutic nutritional supplement includes a predetermined amount of Astragalus to alleviate the symptoms of COPD with its antioxidant and anti-inflammatory effect and its inhibitory action on the goblet cells to attenuate coughing, and to delay the progression of COPD with the activation for stem cells to promote the healing efficacy for injured lung tissue and a predetermined amount of Curcumin to alleviate the symptoms of COPD with its synergistic antioxidant and anti-inflammatory effect, and to delay the progression of COPD with the inhibitory action on the production of the enzyme elastase to prevent the damage of alveoli and to reverse the epigenetic modification caused by chronically exposing to tobacco smoke, an air-polluted, and an chemical fume environment, wherein the nutritional supplement can be utilized in beverages, foods, supplements, and drugs.