RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL;RESEARCH INSTITUTE AT NATIONWIDE CHILDRENS HOSPITAL
发明人:
BAKALETZ, LAUREN O.,GOODMAN, STEVEN D.
申请号：
CA2993009
公开号：
CA2993009A1
申请日:
2016.08.01
申请国别(地区):
CA
年份:
2017
代理人:
摘要：
This disclosure provides isolated or recombinant polypeptides that are useful to vaccinate individuals suffering from chronic/recurrent biofilm disease or as a therapeutic for those with an existing infection. The individual's immune system will then naturally generate antibodies which prevent or clear these bacteria from the host by interfering with the construction and or maintenance of a functional protective biofilm. Alternatively, antibodies to the polypeptides can be administered to treat or prevent infection. Bacteria that are released from the biofilm by our technology are more readily cleared by the remainder of the host's immune system.
