KATIBAH, GEORGE EDWIN,KANNE, DAVID,SUNG, LEONARD,GAUTHIER, KELSEY,GLICKMAN, LAURA HIX,LEONG, JUSTIN,MCWHIRTER, SARAH M.,DUBENSKY, THOMAS W., JR.
申请号：
CA2979215
公开号：
CA2979215A1
申请日:
2016.03.09
申请国别(地区):
CA
年份:
2016
代理人:
摘要：
The present invention provides highly active cyclic-di-nucleotide (CDN) immune stimulators that activate DCs via a recently discovered cytoplasmic receptor known as STING (Stimulator of Interferon Genes), In particular, the CDNs of the present invention are provided in the form of a composition comprising one or more cyclic purine dinucleotides induce human STING-dependent type I interferon production, wherein the cyclic purine dinuclotides present in the composition are 2'-fluoro substituted, bis-3',5'CDNs, and most preferably one or more 2',2"-diF-Rp,Rp, bis-3',5'CDNs.
