KATIBAH, GEORGE EDWIN,KANNE, DAVID,SUNG, LEONARD,GAUTHIER, KELSEY,GLICKMAN, LAURA HIX,LEONG, JUSTIN,MCWHIRTER, SARAH M.,DUBENSKY, THOMAS W.,MCKENNA, JEFFREY,CANHAM, STEPHEN M.,NDUBAKU, CHUDI OBIOMA
申请号：
CA3002236
公开号：
CA3002236A1
申请日:
2016.10.28
申请国别(地区):
CA
年份:
2017
代理人:
摘要：
The present invention provideshighly active cyclic-di-nucleotide (CDN) immunestimulators that activate DCs via a recently discoveredcytoplasmic receptor known as STING(Stimulator of Interferon Genes). In particular, theCDNs of the present invention are provided in theform of a composition comprising one or more cyclicpurine dinucleotides induce human STING-dependenttype I interferon production, wherein thecyclic purine dinuclotides present in the compositionare 2'- or 3'-mono-fluoro substituted, or 2'3'-difluorosubstituted mixed linkage 2',5' - 3',5' CDNs.
