Collagen matrix with locally controlled intrafibrillar and extrafibrillar mineral content and methods of producing

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专利权人:

发明人:

Lester Smith,Stavros Thomopoulos

申请号：

US14169573

公开号：

US09908929B2

申请日:

2014.01.31

申请国别(地区):

US

年份:

2018

代理人:

摘要：

A mineralized collagen matrix with an intrafibrillar and/or extrafibrillar gradient of mineralization for insertion replacement is disclosed. The intrafibrillar mineralization of the collagen matrix is formed by the addition of fetuin to the simulated body fluid. The gradient of intrafibrillar mineralization may stiffen the collagen matrix and simulate a natural insertion for improved cell infiltration and regeneration.

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