GIBSON, Karl Richard,OWEN, Dafydd Rhys,OWEN, Dafydd Rhys,D R 歐文
申请号：
HK18106261.9
公开号：
HK1246783A
申请日:
2018.05.15
申请国别(地区):
HK
年份:
2018
代理人:
摘要：
The invention provides compounds of formula I, wherein: R 1 represents a cyclic group selected from phenyl, heteroaryl 1 , heterocyclyl l and C 3-6 cycloalkyl； wherein each cyclic group is optionally substituted with from 1 to 3 substituents selected from halo, C 1-6 alkyl optionally substituted with 1-3 halogen atoms, phenyl, C 1-6 alkoxy optionally substituted with 1-3 halogen atoms, cyano, heteroaryl 1a and heterocyclyl 1a ； and wherein each cyclic group is optionally fused to a benzene ring or a 5- or 6-membered heteroaromatic or heterocyclic ring each containing from 1 to 3 heteroatoms (selected from N, O and S)； and when the group is substituted the substitution may occur anywhere on the optionally fused ring system as a whole； and wherein heterocyclyl 1 and heterocyclyl 1a may additionally be substituted with =O； X represents a bond or C 1-6 alkylene (which may be straight or branched)； R 2 represents H or C 1-6 alkyl； R 3 represents H or C 1-6 alkyl； Y represents a bond or C 1-6 alkylene (which may be straight or branched, and optionally substituted with OH or CF 3 )； R 4 represents a cyclic group selected from phenyl, heteroaryl 4 , heterocyclyl 4 and C 3-6 cycloalkyl； wherein each cyclic group is optionally substituted with from 1 to 3 substituents selected from halo, C 1-6 alkyl optionally substituted with 1-3 halogen atoms, phenyl, C 1-6 alkyl substituted with phenyl, C 1-6 alkoxy optionally substituted with 1-3 halogen atoms, cyano, heteroaryl 4a and heterocyclyl 4a ； and wherein each cyclic group is optionally fused to benzene ring or a 5- or 6-membered heteroaromatic or heterocyclic ring each containing from 1 to 3 heteroatoms (selected from N, O and S)； and when the group is substituted the substitution may occur anywhere on the optionally fused ring system as a whole； and wherein heterocyclyl 4 and heterocyclyl 4a may additionally be substituted with =O； heteroaryl 1 , heteroaryl 1a , heteroaryl 4
