A topical dermatological/pharmaceutical composition is described that includes BPO wherein the composition is a wash composition with desirable tolerance, stability and foaming properties. The composition can include: a) benzoyl peroxide (BPO)； b) at least one anionic and/or non-ionic surfactant, selected from zinc coceth sulfate； sodium cocoyl isethionate, sodium lauroyl isethionate, C14-C16 &alpha；-olefinsulfonates, preferably its sodium salt and decyl glucoside； c) zinc gluconate； d) dipotassium glycyrrhizate； e) an oily phase； f) an aqueous phase； and g) at least one non-ionic emulsifier from the family of sugar ester derivatives, and/or polyglycerol esters and/or gemini surfactants. The composition is preferably in the form of an oil in water emulsion. Also described, is the use of such composition for the treatment of dermatological disorders, and in particular in the treatment of acne.
