Pharmaceutical compositions Claim 1: A compound having the formula (1) including N-oxides, hydrates, solvates, tautomers, pharmaceutically acceptable salts, prodrugs, mild drugs and their complexes and racemic and scaremic mixtures, their diastereomers and enantiomers, wherein, D is selected from the group consisting of a system of aromatic, heteroaromatic, cycloalkyl or heterocyclic rings, C₁₋₆-heterocyclyl-C (O) alkyl -,1. C833218331c8326 heterosexual asphalt c83321c83126n-n (r8310a) - C (o) -,(r8310) (r8310a) N-C (o) - o-straight bike-c (o)Rectum-c (o) -,-Direct-c (o) -,1. C833218331-832626-o (o) - straight ring-c (o) -,1. C-83218331-c (o) - n (r83100a) - heterosexual-c (o) -,(Alquil C) (Box) N-heterociclil-C (O) -HO-heterocyclyl-C (O) -,Ho-c (o) - straight ring-c (o)1. C83218331-c (o) - o-straight ring-c (o) -,(R⁶) (R⁶) N-C₁₋₆-N (R⁶) -C (O) -heterocyclyl-C (O) -,e. C83218331-832626-heterosexual-c (o) - heterosexual-c (o) - and (r8310a) (r8310a) n-heterosexual-c (o),In this case, each aromatic, heteroaromatic, cyclopropene or heteroaromatic group can be replaced with 1 or more cubic meters of 831222,Independent selection； m is an optional hybrid heterocycle； Z is from - O--S (O) - y -NR -wherein R⁵ is selected from the group consisting of H, optionally substituted C₁₋₅ alkyl, optionally substituted C₁₋₅ acyl and C₁₋₆-O-C (O) alkyl,wherein the C₁₋₆ alkyl is optionally substituted； Ar is a group of the formula (2),Among them, a830808,A83099,A8310a and a8311a were selected independently from N and y-ch groups；As long as there are no more than 2 a83088,A83099,A⁶ and A⁷ can be N, where Ar is optionally substituted； and G is a group of formula (3) where V is a divalent moiety selected from the group consisting of O, S (O) ₀₋₂,NH, N-C₁₋₄ alkyl,N-acyl C₁₋₄,N-alcoxi C -carbonilo NCONH-alcoxi C -carbonilo NSO -alquilo CNQ, NCH₂Q, NCOQ, NCOCH₂Q, NSO₂Q； wherein R³⁸ is selected from the group consisting of C₂₋₆-heterocyclyl alkynyl, H (O) C-,alquil C -C (O) -O-alquil C -C (O)
