CRYSTALLINE FORMS OF SALTS OF FUSED TERA OR PENTA-CYCLIC DIHYDRODIAZEPINOCARAZOLONES, AND USES THEREOF

• 收藏
• 分享

专利权人:

LTD.;BEIGENE

发明人:

Hexiang WANG,Xianzhao KUANG,Changyou ZHOU

申请号：

US16488085

公开号：

US20200157103A1

申请日:

2018.02.27

申请国别(地区):

US

年份:

2020

代理人:

摘要：

Disclosed herein are salts of (R)-2-fluoro-10a-methyl-7,8,9,10,10a,11-hexahydro-5,6,7a,11-tetraazacyclohepta[def]cyclopenta[a]fluoren-4(5H)-one, and crystalline forms (polymorphs) thereof. Also disclosed herein are methods of preparing those crystalline forms, and methods of using at least one of those crystalline forms in treating a cancer responsive to inhibition of PARP, especially a cancer associated with BRCA1/2 mutant activities or other HR deficiencies, in a subject.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/