Yuqiao Shen;Leonard Edwin Post;Ying Feng;Daniel Chu;Bing Wang
发明人:
Daniel Chu,Bing Wang,Ying Feng,Yuqiao Shen,Leonard Edwin Post
申请号：
US13020619
公开号：
US08541403B2
申请日:
2011.02.03
申请国别(地区):
US
年份:
2013
代理人:
摘要：
A compound having the structure set forth in Formula (I) and Formula (II):wherein the substituents Y, Z, A, B, R1, R2, R3, R4 and R5 are as defined herein. Provided herein are inhibitors of poly(ADP-ribose)polymerase activity. Also described herein are pharmaceutical compositions that include at least one compound described herein and the use of a compound or pharmaceutical composition described herein to treat diseases, disorders and conditions associated with a PTEN deficiency that are ameliorated by the inhibition of PARP activity.
