- (substituted benzamides Derivatives, Pharmaceutical compositions containing them and use them to treat Diseases Associated mainly to the central nervous system
The present refers to compounds of the formula (1) in which: R1 is hydrogen, halogen, cyano, lower alkyl, lower alkyl substituted by halogen, lower alkoxy, lower alkoxy substituted by halogen or C (O) NH2, or is phenyl optionally substituted by halogen, cyano, or lower alkoxy substituted by halogen, or is 2,2-difluorobenzo [d] [1,3] dioxol-5-yl, or is 6- (trifluoromethyl) -pyrazin-2-yl or 5 - (trifluoromethyl) -pyrazin-2-yl or is 6- (trifluoromethyl) -pyrimidin-4-yl, or is 6- (trifluoromethyl) -pyridin-3-yl, or is 5-cyanopyrazin-2-yl or is 2 - (trifluoromethyl) pyrimidin-4-yl； n is number 1 or 2； R2 is halogen, lower alkyl or cyano and R3 is hydrogen,R2 is hydrogen, R3 is halogen, low tar or cyanogen； X is a link, NR rsqoe； -,-CH2NH- or -CHR-；R rsqoe； is hydrogen or lower tar； Z is a bond, ch2-u-o -；Ar is phenyl or is heteroaryl chosen from the group consisting of 1H-indazol-3-yl, pyridin-2-yl, pyridin-3-yl, pyridin-4-yl, pyrimidin-5-yl, 1H-pyrazole-3- yl, 1H-pyrazol-4-yl and 1H-pyrazol-5-yl； or a pharmaceutically appropriate acid addition salt thereof； which can be used to treat depression, anxiety disorders, bipolar disorder, attention deficit hyperactivity disorder (ADHD),Diseases related to stress, psychosis, schizophrenia, neurological diseases, Parkinson's disease, neurodegenerative diseases, Alzheimer's disease, epilepsy, migraine, hypertension, drug abuse, metabolic disorders, Eating disorders, diabetes, diabetic complications, obesity, defatting, energy intake and digestion disorders, body temperature homeopathy and dysfunction, sleep and cirrhosis disorders, and cardiovascular diseases.La presente se refiere a compuestos de la fórmula (1) en la que: R1 es hidrógeno, halógeno, ciano, alquilo inferior, alquilo inferior sustituido por halógeno, alcoxi inferior, alcoxi inferior sustituido por halógeno o C(O)NH2, o es fenilo opcionalmente sustituido por halógeno, ciano o alcoxi inferior sustituido por halógeno, o es 2,2-difluorobenzo[d][1,3]dioxol-5-ilo, o es
