Adrian Folkes,Stephen Shuttleworth,Irina Chuckowree,Sally Oxenford,Nan Chi Wan,Georgette Castanedo,Richard Goldsmith,Janet Gunzer-Toste,Tim Heffron,Simon Mathieu,Alan Olivero,Daniel P. Sutherlin,Bing-
申请号：
US14316166
公开号：
US09943519B2
申请日:
2014.06.26
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Compounds of Formulae Ia, and stereoisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, are useful for inhibiting lipid kinases including PI3K, and for treating disorders such as cancer mediated by lipid kinases. Methods of using compounds of Formula Ia for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.
