REGENTIS INTERNATIONAL;UNIVERSITE DE REIMS CHAMPAGNE ARDENNE;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
发明人:
HORNEBECK WILLIAM,ATTIA JOAN,LORIMIER SANDRINE,ANTONICELLI FRANK
申请号：
NZ62866013
公开号：
NZ628660A
申请日:
2013.01.31
申请国别(地区):
NZ
年份:
2015
代理人:
摘要：
Discloses a bifunctional peptide capable of activating the synthesis of collagen and inhibiting the production of matrix metallo-proteinases, wherein it has a sequence having three peptide portions A, B and C: - the first peptide portion A corresponding to a hexapeptide repeated at least three times, said portion A being capable of bonding to an elastin-binding receptor protein in order to stimulate the collagen synthesis, - the second peptide portion B corresponding to a tetrapeptide capable of acting as a competitive inhibitor of the urokinase protease and of being cleaved by said protease, and - the third peptide portion C corresponding to a tripeptide occupying at least one active site of the matrix metallo-proteinases in order to permit an inhibition of said proteinases. Also discloses cosmetic and pharmaceutical compositions comprising such a peptide, and related uses in treating scarring, pressure sores, or regenerating dermal tissues or the treatment of skin aging.
