LINZ, KLAUS,ZEMOLKA, SASKIA,NOLTE, BERT,SCHUNK, STEFAN,SCHICK, HANS
申请号：
PE0001502013
公开号：
PE08082013A1
申请日:
2011.07.27
申请国别(地区):
PE
年份:
2013
代理人:
摘要：
CIS refers to Derivatives of tetrahydro - Spiro (ciclohexan - 1,1 - pirido [3,4-b] indole Amine) - 4, characterized in that include compounds of General formula (i), wherein R1 is Hydrogen, CH3 R2 and R3 are h, halogen R4 and R5 is H, halogen, C1 - C3 alkyl, among others Q1 - Q2 form - CH2 = CH - - - Cr6 R6 and R7 are h, together form a Ring of Five Elements On The Bridge - S -, among others.Preferred compounds are: 2 - (4-chlorophenyl) - 1 - ((1S, 4S) - 4 - (dimethylamino) - 4 - (3-fluorophenyl) - 3 , 4 - dihydro - ciclohexan spiro [- 1,1 - pirido [3,4-b] indole] (9 - 2 (H) - il) ethanone benzo [b] - tiofen 2il ((1S, 4S) - 4 - (dimethylamino) - 4 - (3-fluorophenyl) - 3, 4 - dihydro - ciclohexan spiro [- 1,1 - pirido [3,4-b] indole] (9 - 2 (H) - il) i Tanona, among others. It also relates to a Pharmaceutical formulation.These compounds are useful for the treatment of neuropathic pain and chronic.SE REFIERE A DERIVADOS DE CIS-TETRAHIDRO-ESPIRO(CICLOHEXAN-1,1-PIRIDO[3,4-B]INDOL)-4-AMINA, CARACTERIZADOS PORQUE COMPRENDEN COMPUESTOS DE FORMULA GENERAL (I), EN DONDE R1 ES HIDROGENO, CH3 R2 Y R3 SON H, HALOGENO R4 Y R5 ES H, HALOGENO, ALQUILO C1-C3, ENTRE OTROS Q1-Q2 FORMAN -CH2-, -CR6=CH- R6 Y R7 SON H, JUNTOS FORMAN UN ANILLO DE CINCO ELEMENTOS SOBRE EL PUENTE -S-, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: 2-(4-CLOROFENIL)-1-((1s,4s)-4-(DIMETILAMINO)-4-(3-FLUOROFENIL)-3,4-DIHIDRO-ESPIRO[CICLOHEXAN-1,1-PIRIDO[3,4-b]INDOL]-2(9H)-IL)ETANONA BENZO[b]TIOFEN-2IL((1s,4s)-4-(DIMETILAMINO)-4-(3-FLUOROFENIL)-3,4-DIHIDRO-ESPIRO[CICLOHEXAN-1,1-PIRIDO[3,4-b]INDOL]-2(9H)-IL)METANONA, ENTRE OTROS. SE REFIERE TAMBIEN A UNA FORMULACION FARMACEUTICA. DICHOS COMPUESTOS SON UTILES PARA EL TRATAMIENTO DEL DOLOR NEUROPATICO Y CRONICO.
