Various methods and systems are provided for a guided at-home ultrasound imaging session. In one example, a system for ultrasonically scanning a tissue sample includes a hand-held ultrasound probe including a transducer array of transducer elements, a probe position tracking device including one or more position sensors coupled to the ultrasound probe, and a controller. The controller is configured to, during an imaging session, determine a position of the ultrasound probe relative to a target position based on position data collected by the probe position tracking device, and responsive to an indication that the ultrasound probe is at the target position, acquire image data with the transducer array.
