GHAYUR TARIQ,HUTCHINS CHARLES W.,GU JIJIE,LIU JUNJIAN
申请号：
ARP110104872
公开号：
AR084531A1
申请日:
2011.12.22
申请国别(地区):
AR
年份:
2013
代理人:
摘要：
In addition, there is also provided a pharmaceutical component, which includes the published polymerized protein. Claim 1: a binding protein, which is composed of a series of polypeptides, characterized in that the polypeptide chain is composed of VD1 - (x1) n-x2, wherein VD1 includes a domain binding with heavy chain antigen； X1 includes The domains selected from the group include polypeptide, ch1 domain, CH2 domain, ch1 domain, CH2 domain and connector； n is 0 or 1； x2 includes polypeptide, at least a part of CH3 domain,In this case, the binding protein includes at least one residue mutation to inhibit the secondary action of ch3-ch3, in which case, the binding protein forms a binding site with the functional antigen. 150. Claim 157: a mixture of binding proteins, characterized by comprising the binding proteins as described in any one of claims 1 to 156, in addition to an agent selected from the group； an immunoenzyme molecule, an image agent,A therapeutic agent and a cytotoxic agent Claim 170: a nucleic acid characterized in that the polypeptide in any one of the requirements 1 to 165 is encoded. Claim 173: the use of polymerized protein in any one of claims 1 to 165, characterized by the preparation of a drug for the treatment of a disease or condition selected by groups such as arthritis, osteoarthritis, chronic arthritis in youth, meconization, Lyme arthritis, etc, Psychoarthritis, reactive arthritis, cavernous aneurysm, systemic lupus erythematosus, Crohn's disease, ulcerative colitis, inflammation,Insulin dependent diabetes, thyroiditis, asthma, allergic disease, rash, dermatitis, scleroderma, transplantation and host disease, rejection of organ transplantation, acute or chronic immune diseases related to organ transplantation, scabies, ammonia, scattered intravascular coagulation, Kawasaki disease, serious disease, nephrotic syndrome, chronic fatigue, Wegener mumps, Henoch scholenein purple, microscopical nephritis, active chronic hepatitis, young people,
