The present invention relates to novel heterocyclic diphenyl ether and diphenyl amine compounds, derivatives, analogs, tautomeric forms, stereoisomers, polymorphs, hydrates, solvates, pharmaceutically acceptable salts and pharmaceutically acceptable solvates thereof and pharmaceutically acceptable compositions containing these singly or in combination. The compounds of the present invention are effective in lowering blood glucose, serum insulin, free fatty acids, cholesterol and triglyceride levels and are useful in the treatment and / or prophylaxis of diabetes. The compounds of the present invention are effective in treatment of obesity, inflammation, autoimmune diseases such as multiple sclerosis and rheumatoid arthritis and immunological diseases, including the treatment of cancer. Furthermore, the compounds are useful for the treatment of disorders associated with insulin resistance.本發明有關新穎之雜環二苯基醚及二苯基胺類化合物、其衍生物、類似物、互變異構形式、立體異構物、多晶型物、水合物、溶劑合物、醫藥上可接受之鹽及醫藥上可接受之溶劑合物及含有單一或組合之此等化合物的醫藥上可接受之組成物。本發明化合物可有效地降低血糖、血清胰島素、游離脂肪酸、膽固醇及三酸甘油酯水平，且可用於治療及/或預防糖尿病。本發明化合物可有效地治療肥胖、發炎、自體免疫性疾病(諸如多發性硬化及類風濕性關節炎)及免疫性疾病，包括治療癌症。此外，該等化合物可用於治療與抗胰島素現象有關之病症。
