The present invention discloses a FXR agonist, its preparation method and the use thereof. Specifically, the invention relates to a compound represented by the formula (I), its stereoisomers or pharmaceutically acceptable salts thereof. The series of compounds can be used to treat FXR mediated diseases, including cardiovascular disease, atherosclerosis, arteriosclerosis, hypercholesterolemia, hypercholesterolemic chronic hepatitis disease, chronic liver disease, gastrointestinal disease, nephrosis, metabolic disease, cancer like colorectal cancer or neurological signs such as stroke and other diseases. It is expected to be developed into a new generation of FXR agonists for a wide range of medical applications.本發明公開FXR激動劑及其製備方法和應用，具體涉及具有式(I)結構的化合物、其立體異構體或其藥學上可接受鹽。該系列化合物可以用於治療FXR介導的疾病，包括心血管疾病、動脈粥樣硬化、動脈硬化、高膽甾醇血、高血脂慢性肝炎疾病、慢性肝病、胃腸疾病、腎病、代謝疾病、癌症(例如結直腸癌)或神經跡象如中風等疾病，具有廣泛醫學應用，有望開發成新一代FXR調控劑。
