MEI-HUI WANG,Wuu-Jyh Lin,Hung-Man Yu,Chuan-Yi Chien,Ping-Yen Wang
申请号：
US13243225
公开号：
US20120107236A1
申请日:
2011.09.23
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present invention is related to a pharmaceutical composition for a liver-receptor imaging injection, the pharmaceutical composition including a bi-functional compound which has a ASGPR specificity, wherein the bi-functional compound includes a backbone of alpha-amino acid (or the derivatives thereof) and a poly-galactosamine chain (or a poly-lactose chain) connected to the alpha-amino acid. Thereby, the pharmaceutical composition can quantify potential of liver storage ability and evaluate severity of the course of liver disease. A liver-receptor imaging injection using the same and the one-step dispensing method thereof are also provided to improve defects of iodine-labeled and overcome disadvantages of the reduced labeling-yield and the instability after autoclave sterilization.
