GODESSART MARINA NURIA,PIZCUETA LALANZA, MARIA PILAR
申请号：
NZ58908909
公开号：
NZ589089A
申请日:
2009.06.18
申请国别(地区):
NZ
年份:
2012
代理人:
摘要：
Disclosed is a combination which comprises (a) methotrexate and (b) a DHODH (dihydroororate dehydrogenase) inhibitor of formula (I). Specific examples of DHODH inhibitors of formula (I) include: 2-(3-Fluoro-3'-methoxybiphenyl-4-ylamino)nicotinic acid, 2-(3-Chloro-3'-methoxybiphenyl-4-ylamino)nicotinic acid, and 2-(3'-cyclopropoxy-3,5-difluorobiphenyl-4-ylamino)nicotinic acid. The combination of methotrexate and a DHODH inhibitor of formula (I) is useful for treating rheumatoid arthritis, psoriatic arthritis, ankylosing spondilytis, multiple sclerosis, Wegener's granulomatosis, systemic lupus erythematosus, psoriasis and sarcoidosis.
